Camelid immunoglobulins and nanobody technology
نویسندگان
چکیده
منابع مشابه
(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.
Nanobodies are single chain antibodies that are uniquely produced in Camelidae, e.g. camels and llamas. They have the desirable features of small sizes (Mw < 14 kDa) and high affinities against antigens (Kd approximately nM), making them ideal as structural probes for biomedically relevant motifs both in vitro and in vivo. We have previously shown that nanobody binding to amyloidogenic human ly...
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Objective(s): Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities. Their minimal size assists in reaching otherwise largely inaccessible regions of antigens. However, their camelid origin raises a possible concern of immunogenicity when used for human therapy. Humanization is...
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ژورنال
عنوان ژورنال: Veterinary Immunology and Immunopathology
سال: 2009
ISSN: 0165-2427
DOI: 10.1016/j.vetimm.2008.10.299